Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin.

Submitted by job2075 on September 11, 2018 - 4:25pm

Title	Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin.
Publication Type	Journal Article
Year of Publication	2014
Authors	Flory JH, Small DS, Cassano PA, Brillon DJ, Mushlin AI, Hennessy S
Journal	J Comp Eff Res
Volume	3
Issue	1
Pagination	29-39
Date Published	2014 Jan
ISSN	2042-6313
Keywords	Administration, Oral, Age Factors, Aged, Body Mass Index, Comparative Effectiveness Research, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Male, Middle Aged, Retrospective Studies, Sex Factors
Abstract	AIMS: To provide evidence on the comparative effectiveness of oral diabetes drug combinations. METHODS: We performed a retrospective, observational cohort study of glycosylated hemoglobin change in outpatients newly exposed to dual- or triple-drug oral diabetes treatment. RESULTS: Adjusted response to a second drug added to metformin ranged from 0.85 to 1.21% glycosylated hemoglobin decline. Response to a third drug was smaller (0.53-0.91%). Higher baseline glycosylated hemoglobin was associated with larger response; sulfonylurea effectiveness declined over time; and thiazolidinediones were more effective in obese patients and women. CONCLUSION: Observational data provide results qualitatively consistent with the limited available randomized data on diabetes drug effectiveness, and extend these findings into common clinical scenarios where randomized data are unavailable. Sex and BMI influence the comparative effectiveness of diabetes drug combinations.
DOI	10.2217/cer.13.87
Alternate Journal	J Comp Eff Res
PubMed ID	24345255
PubMed Central ID	PMC3996558
Grant List	UL1 RR024996 / RR / NCRR NIH HHS / United States UL1 TR000457 / TR / NCATS NIH HHS / United States

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Faculty Publication