ROMA (2018-2027, CIHR):A multinational RCT Comparison of the Clinical Outcome of Single vs. Multiple Arterial Grafts with >4,000 patients being recruited from >50 sites in six continents.
ROMA:Women (CIHR):A multinational RCT Comparison of the Clinical Outcome of Single vs. Multiple Arterial Grafts with 2,000 women.
ODIN (2030, CIHR):A multinational RCT Comparison of one-month dual antiplatelet therapy plus aspirin versus aspirin alone after coronary artery bypass grafting with 700 patients.
SMARTFLOW (Industry-funded).A multinational RCT Comparison of transit time flow measurement versus standard of care in Coronary Artery Bypass Grafting (1,242 patients).
STICH-3C (CIHR funded). A multinational RCT comparing Coronary Arterial Bypass Grafting to Percutaneous Coronary Intervention in patients with heart failure (754 patients).
PALACS (philanthropic funding, PI: Gaudino). Single-center comparison of Posterior Pericardiotomy versus standard of care in patients undergoing Coronary Artery Bypass Grafting (420 patients).
BEAT-AF (serves as DCC, starting in China for enrollment): A single-center RCT Comparison of amiodarone patches versus standard of care in Coronary Artery Bypass Grafting (500 patients).
SWITCH Swedeheart (funded by Sweden)A registry-based, stepped-wedge, cluster-randomized, open-label, multicenter trial comparing prasugrel and ticagrelor for the treatment of patients with acute coronary syndrome (~14,000 patients).
STICH-Swedeheart (Sweden scientific research council, Redcap currently in sweden, Sister study to STICH-3C): A multinational RCT comparing Coronary Arterial Bypass Grafting to Percutaneous Coronary Intervention in patients with heart failure (470 patients).
STICH Consortium (Analytical unit)
Paired Vagus Nerve Stimulation (VNS) in Chronic Stroke (NIA funded): A randomized, blinded, sham-controlled mechanistic trial.
DEPRESCRIBE-HFpEF (NIA-funded): Determining Evidence in a Placebo-Controlled, Randomized Experiment Studying Continuation vs. Removal of Inessential Beta-Blockers in Elders with Heart Failure with Preserved Ejection Fraction (HFpEF).
Real World Data Analysis Support Projects
Target Trial Emulation NIH-RECOVER-EHR (1 OT2 HL161847-01): Target trial emulation for validation of existing or generating new treatment hypotheses that could be protective of long COVID.
Target Trial Emulation for Drug Repurposing Hypotheses Generation for Alzheimer’s Disease (1 R01 AG080991-01 and 1 R01 AG076234-01): Target trial emulation for drug repurposing hypothesis generation from large scale EHR data.
Voice Signal analysis NIH Bridge-to-AI Voice as a Biomarker Project (1 OT2 OD032720-01): Analyzing acoustic signals for identification of patients with swallowing problems.
Heart Failure Prediction with Multi-Modal Data (NYP Cardiology AI Initiative CT 232441-01): Predicting the cardiopulmonary exercise testing (CPET) results with echocardiogram; Opportunistic screening for LVEF abnormalities with chest CT.
Patient Similarity Analytics for All-of-Us Data (1 R21 LM014454-01): Identification of similar patients in AoU and obtain aggregated practice-based evidence from the EHR data in AoU cohort.
AHA Stroke Subtype Classification (AHA 230945-01): Identification of stroke subtypes from clinical and genetic data.
HSS Arthritis Subtype Identification (HSS Service Contract HSS 233101-01): Identification of subtypes of osteoarthritis and rheumatoid arthritis with multi-modal data including clinical data, patient reported outcomes, pathology slides and genomics.
