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Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients.

TitleObesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients.
Publication TypeJournal Article
Year of Publication2019
AuthorsGreenlee H, Shi Z, Hibshoosh H, Giri DD, Ahmed A, Williams S, Falcone DJ, Winston LA, Zhou XK, Hudis CA, Hershman DL, Dannenberg AJ, Iyengar NM
JournalCancer Prev Res (Phila)
Volume12
Issue1
Pagination21-30
Date Published2019 Jan
ISSN1940-6215
Abstract

Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5-<25.0 kg/m), overweight (25.0-<30.0 kg/m), class I obesity (30.0-<35.0 kg/m), and class II-III obesity (35.0 kg/m or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36-96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II-III obesity; <0.01). Severe BWATi (>0.27 CLS-B/cm) was associated with higher BMI ( = 0.046) and greater adipocyte diameter ( = 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.

DOI10.1158/1940-6207.CAPR-18-0207
Alternate JournalCancer Prev Res (Phila)
PubMed ID30404870
PubMed Central IDPMC6663483
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States
P30 CA013696 / CA / NCI NIH HHS / United States
R25 CA203650 / CA / NCI NIH HHS / United States
U54 CA210184 / CA / NCI NIH HHS / United States
Division: 
Biostatistics
Category: 
Faculty Publication