|Title||Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Greenlee H, Shi Z, Hibshoosh H, Giri DD, Ahmed A, Williams S, Falcone DJ, Winston LA, Zhou XK, Hudis CA, Hershman DL, Dannenberg AJ, Iyengar NM|
|Journal||Cancer Prev Res (Phila)|
|Date Published||2019 Jan|
Breast white adipose tissue inflammation (BWATi) is associated with obesity and higher breast cancer risk among non-Hispanic white women. Obesity is prevalent in Hispanic/Latina patients with breast cancer, and the occurrence of BWATi in this population is not well-characterized. The association between BWATi and body mass index (BMI) was evaluated in Hispanic/Latina patients with breast cancer who underwent mastectomy. BWATi was defined as the presence of crown-like structures of the breast (CLS-B), detected by CD68 IHC in nontumor breast tissue. BWATi severity was quantified as number of CLS-B/cm Adipocyte diameter was measured using hematoxylin and eosin-stained breast tissue sections. Preoperative BMI (within 1 week prior to mastectomy) was categorized as normal (18.5-<25.0 kg/m), overweight (25.0-<30.0 kg/m), class I obesity (30.0-<35.0 kg/m), and class II-III obesity (35.0 kg/m or above). Patient charts were abstracted to record clinicopathologic features and liver function tests <90 days before mastectomy. The study included 91 women (mean age 69 years; range 36-96 years). Prevalence of BWATi increased with BMI (24% in normal weight, 34% in overweight, 57% in class I obesity, and 65% in class II-III obesity; <0.01). Severe BWATi (>0.27 CLS-B/cm) was associated with higher BMI ( = 0.046) and greater adipocyte diameter ( = 0.04). Adjusting for BMI, neoadjuvant chemotherapy, and elevated alanine aminotransferase were associated with severe BWATi, and current smoking was associated with mild BWATi (all < 0.05). BWATi was associated with higher BMI in Hispanic/Latina patients with breast cancer, consistent with previously described associations in other populations.
|Alternate Journal||Cancer Prev Res (Phila)|
|PubMed Central ID||PMC6663483|
|Grant List||P30 CA008748 / CA / NCI NIH HHS / United States |
P30 CA013696 / CA / NCI NIH HHS / United States
R25 CA203650 / CA / NCI NIH HHS / United States
U54 CA210184 / CA / NCI NIH HHS / United States
Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients.
Submitted by chz4003 on August 12, 2019 - 12:45pm